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Vitamin E, together with vitamin A, C, and D, directly influences not only the oxidantantioxidant balance and oxidative stress, but also the inflammation induced by oxidative stress, as described below

Establishing new more holistic methods to evaluate MS treatment outcomes Biogen, along with academic partners, leveraged the AVONEX trial to introduce four clinical trial innovations that subsequently became standard practice, shaping the MS clinical development field

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10.1038/s41419-020-2404-5 139 NurchiV

This transition is mediated by factors such as VEGF and TGF-, which lead to endothelial cells acquiring mesenchymal characteristics [38]