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American heart association congenital cardiac defects committee CoCDitY: Gengtic basis for congenital heart defects: current knowledge: a scientific statement from the American heart association congenital cardiac defects committee, council on cardiovascular disease in the young: endorsed by the American academy of Pediatrics

This intense metabolic activity significantly increases the production of free radicals, especially reactive oxygen species (ROS)

a active metabolite is also metabolized by CYP2D6

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Cell death was assessed after 16 h by LDH release assay