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Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25

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For individuals pursuing depigmentation goals, physicians often recommend one to three sessions per week initially, depending on baseline skin tone, oxidative stress levels, and overall health status

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Biochim Biophys Acta BBA - Rev Cancer