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Through in silico analyses, the authors hypothesized that this effect could be due to the high binding affinity of VitB12 with the CD14 receptor that could inhibit LPS transport and thereby, avoid TLR4 activation (Figure 4A) [82]

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Accurately predicting protein pK a values using nonequilibrium alchemy

Moreover, the maintenance or increase in skeletal muscle glutamine concentration might be fundamental for muscle protein synthesis [127,128,129], to prevent muscle atrophy [38, 130] and to increase glycogen synthesis [131], particularly under catabolic conditions