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22 Interestingly, the disruption to EC junctions seems to be repaired after paracellular extravasation, without significant damage to the BBB

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When artemisinin consumes heme 25,26 (or iron 27 ) and produces free radicals or heme-artemisinin adducts to inhibit heme crystallization 28 , even accelerating the breakdown of hemozoin 5 , it simultaneously inevitably interferes the normal formation and degradation of hemozoin, uses up iron by forming iron-artemisinin within the parasites, interferes or interrupts the transport and utilization of iron, thereby finally leading to death of the malaria parasites

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