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Baum P, Kosacka J, Estrela-Lopis I, Woidt K, Serke H, Paeschke S, et al

If you are constantly stressed, you "burn through" your antioxidant reserves much faster than your liver can replenish them

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A meta-analysis of randomized, controlled trials found that DHEA supplementation significantly decreased cortisol levels (Chen 2021)

PON1 is susceptible to being partially inactivated by the metabolic products of oxidative stressspecifically, by oxidized glutathione (GSSG) through the process of S-glutathionylation and by products of lipid peroxidation, which can also react with the free sulfhydryl group of the enzyme (Aviram et al., 1999