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Beyond enzyme regulation, GHK-Cu acts as a potent epigenetic modulator, influencing the expression of a large fraction of human genes upregulating pathways involved in antioxidant defense, DNA repair, and tissue remodeling while downregulating inflammatory and pro-fibrotic signaling

A1 astrocytes are distinguished by hypertrophy, reduced expression of essential ion channels and neurotransmitter receptors, and upregulated glial fibrillary acidic protein (GFAP) expression, ultimately disrupting the BBB (44)

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doi: 10.1080/17512433.2022.2117155 62 Practice Committee of the American Societyfor Reproductive Medicine

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