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The astrocyte endfeet are enriched with aquaporin channels, which mediate water exchange across the blood-spinal cord barrier and the BBB, control cell and extracellular space volume, and astrocyte migration (Salman et al., 2022)

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Neuroleptic malignant syndrome: a review from a clinically oriented perspective

Even when NPs are intended to traverse the bloodbrain barrier (BBB) for CNS delivery, neurotoxicity remains a concern: NPs can activate microglia, promote neuroinflammation, trigger excitotoxicity, and accumulate in neural tissue even without brain-targeting ligands

Multiple sessions are often required for noticeable results, and maintenance treatments may increase the cost