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Activation of the NLRP3 inflammasome represents a key step in IL-1 production during HIRI, further promoting neutrophil recruitment and amplification of the inflammatory response (45)

The ability of these neoantigens to evoke such responses in patients with LS-CRC, as well as in individuals with LS who have yet to develop LS-associated cancers, suggests that they may be potential effective targets for vaccine-based therapy

Am J Respir Cell Mol Biol 41:722730

Rev Bras Farmacogn 29:319324 Rasul A, Millimouno FM, Ali Eltayb W, Ali M, Li J, Li X (2013) Pinocembrin: a novel natural compound with versatile pharmacological and biological activities

Furthermore, in vitro and in vivo models of intracerebral hemorrhage were created by treating BV2 cells with hemoglobin and intraventricular injection of type IV collagenase into Sprague-Dawley rats, respectively