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Nevertheless, this increased autophagic activity becomes compromised in the presence of diabetes, both in living organisms and under elevated glucose conditions in laboratory settings ( Numerous reports indicate that uremic waste can contriute to mitochondrial dysfunction and hypermethylation of the Klotho gene, both of which are pivotal in the senescence of DN cells (Sun et al., 2017

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In addition, although GR-6 and GR-7 were found to carry virulence genes, they do not harbor antibiotic resistance genes and demonstrated no significant virulence risks under the tested conditions (Supplementary Fig

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