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Here, we show that culturing lymphoid cells in 3D gels triggers reactive oxygen species (ROS) production, leading to non-tumor lymphoid cell death while enabling the survival and proliferation of a subset of lymphoma/leukemia cells, TICs or TIC-like cells

The composition according to any of claims 1 -836, wherein the one or more pharmamers comprises a dextran carrier with Simian MHC class 1 molecules attached