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Ikeda H, Shiojima I, Ozasa Y et al (2009) Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy

PubMed, Chen, J., et al

Synergy is inferred from the individual mechanisms, not demonstrated in combination: GHK-Cu: Cosmetically Focused Clinical Data Split-face human dermatology trials on wrinkle depth and skin density (n usually under 50 per arm) Microarray gene mapping (4,000+ genes)

Then the rules changed

Significantly less Botox was discovered in milk than the dose that was administered, indicating that very little, if any, makes its way into breast milk after treatment