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While FMO3 inhibitors reduce TMAO levels, they risk adverse effects like hepatic inflammation, and individuals with FMO3 gene defects may develop trimethylaminuria (fish odour syndrome)

Another key player in -KG generation is the mitochondrial enzyme GDH1, which contributes to the accumulation of the subsequent metabolite fumarate

For example, the Medline search included: exp Fibromyalgia/or fibromyalgia.mp

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