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Acknowledgements We thank Yale School Medicine, Yale West Campus, Systems Biology Institute and Cancer Biology Institute for the instrumentation supports

This condition manifests as flat brownish or blue-grey patches, primarily on the face, predominantly affecting women

Although we observed a reduction in total A, A 42 is the predominant isoform within plaques

This finding brought together the antioxidant property of UA with the consistently topical concept of oxidative stress as a critical factor in the pathogenesis of PD

In particular, H 2 S, considered highly toxic, a poisonous gas with a typical odor of rotten eggs, is now classified among the endogenously produced gasotransmitters involved in many cell homeostatic processes as nitric oxide (NO) and carbon monoxide (CO), each other interacting [44,45]