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The PCA results emphasize the inherent variability within our dataset and provide insights into the primary factors driving the observed trends

As a single transmembrane receptor, the low-density lipoprotein receptor (LDLR) plays an important role in maintaining the homeostasis of intracellular cholesterol metabolism, in which exogenous cholesterol is internalized into the low-density lipoprotein (LDL) and taken up by the cell after binding to the LDLR on the cytosolic membrane [198]

doi: 10.2147/COPD.S135338 124 MaguireJ

Khan S, Aziz S, Waqas M, Kakar MA, Ahmad S

However, in GCLM KO mice, genes encoding lipid synthesis enzymes, Fasn and Scd , were further down-regulated, whereas Fads1 was up-regulated by ethanol, the net effect of which would be expected to result in lower levels of total TG and increases in the relative abundance of certain lipid species