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Such extensive viral ORF/protein interactions with host-specific cellular targets could trigger severe HMRD, a rewiring of sugar-, AA-, FA-, and nucleotide-metabolism(s)

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Fig 2 confirms that the maximum change in GSH Total was greater following NLNG compared to placebo in most participants

Moreover, we highlight recent therapeutic advances including the Food and Drug Administration (FDA) approval of resmetirom in 2024 and other promising agents currently in phase 2/3 trials providing a timely and translationally relevant overview that bridges current scientific evidence with emerging clinical applications in MASLD