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Exercise studies in healthy young men showed that skeletal muscle MOTS-c levels increase nearly 12-fold after acute exercise, suggesting this peptide mediates some of the metabolic benefits of physical activity

They can support energy metabolism and fat transport, especially in individuals with low B12 or metabolic sluggishness

Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency

B vitamins are consumed at higher rates during intense exercise due to their central role in energy metabolism and tissue repair

However, taking both a standalone B12 and a B complex at the same time is usually unnecessary since a good B complex already contains B12