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Dark marks remain on the skin after inflammation heals

In a clinical study conducted by Okuyama et al

In patients with chronic stable angina pectoris complicated by depression and anxiety, Melissa officinalis supplements have shown significant improvement in symptoms

Cell Death Discov 11:128 Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA et al (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

The lack of universal dosing protocols, as well as abuse outside of medical supervision, work to heighten these issues of safety