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As lipid peroxyl radicals propagate the reaction, they generate lipid hydroperoxides and highly toxic byproducts such as MDA and 4-HNE ( The impact of lipid peroxidation on sperm function is profound
In responding patients, anti-PD-1 therapy drives differentiation of precursor cells (either nave T cells or progenitor-like Texh) into differentiated effector-like Texh, increasing cytotoxic function
Disclosures: Savvoula Savvidou: Nothing to Disclose, Polyxeni Agorastou: Nothing to Disclose, Effrosyni Tsirogianni: Nothing to Disclose, Stefania Kiapidou: Nothing to Disclose, Ioanna Papagiouvani: Nothing to Disclose, Theodora Oikonomou: Nothing to Disclose, Lazaros Sideras: Nothing to Disclose, Prodromos Hytiroglou: Nothing to Disclose, Ioannis Goulis: Nothing to Disclose 854 DIFFERENTIATION OF STEATOTIC LIVER DISEASE FROM ADVANCED LIVER FIBROSIS/CIRRHOSIS BY BREATH VOLATILE ORGANIC COMPOUND ANALYSIS Vaclav Smid 1 Ksenyia Dryahina 2 Barbora Novkov 1 Stefan Swift 3 Simon Dostal 1 Sarka Svobodova 1 Martin Lenicek 1 Patrik Spanel 2 Radan Bruha 1 , 1 General University Hospital and First Faculty of Medicine, Prague, Czech Republic, 2 J
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