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DNA sequencing was performed by Illumina technology (Eurofins, Germany)

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Proinflammatory cytokines such as TNF and IL-1 were significantly increased following sepiapterin supplementation as was soluble intercellular adhesion molecule-1 (sICAM-1), chemokine (C-X-C motif) ligand 1 (CXCL1/KC) and TIMP metallopeptidase inhibitor 1 (TIMP-1)