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Gruber, K., Puffer, B

Ranolazine study group

4614-C DOWNREGULATION OF SOX9 MEDIATED BY REDUCED NOTCH AND HIPPO SIGNALING RESULTS IN BILE DUCT PAUCITY AND IMPAIRED DUCTULAR REACTION IN AN iPSC-DERIVED, HUMAN, THREE-DIMENSIONAL MODEL OF ALAGILLE SYNDROME Marie-Agns M'Callum, Silvia Selleri, Quang Toan Pham, Alexandre Archambault-Marsan, Kristen Vieira-Lomasney and Massimiliano Paganelli, CHU Sainte-Justine, Universit De Montral Background: Alagille syndrome (ALGS) is an autosomal dominant multisystemic disease resulting in bile duct paucity, cholestasis and progressive fibrosis

These included: simple update (consumption reported on the most recent FFQ before each follow-up interval)

Maintenance Phase This phase lasts from several months to years