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The EFSAs tolerable exposure level for Cd was 0.36 g/kg body weight per day, and a threshold level was [5,6]

N-Acetylcysteine attenuates the anxiety-like behavior and spatial cognition impairment induced by doxorubicin and cyclophosphamide combination treatment in rats

Interactions between cationic peptides and negatively charged oligonucleotides can enhance toxicity, affect pharmacokinetic and pharmacological properties, and limit the efficacy of these therapies

Moreover, previous reports of renal impairment studies do not consistently show that the variability of C max or other PK parameters such as AUC is higher in participants with renal impairment than in healthy participants after IV administration over a short period of time [19, 20]

10.1186/s12967-018-1756-4 J Transl Med