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One proposed hypothesis, as yet untested, is that high-dose folic acid supplements cause depletion of the transport protein holotranscobalamin in serum, thus exacerbating B12 deficiency

Vitamin B12 and its derivatives catalytic activity are heavily reliant on the existence of the nucleotide loop and can be affected by reducing agents, solvents, and light

Theres no question that the use of many of these has surged, in part because of their putative anti-aging effects or other unsubstantiated health claims, along with endorsements by celebrities, longevity, and wellness influencers

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