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Coqueret, Escape from p21-mediated Oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins

In 2015, a Cognitive Vitality Report released by the Alzheimers Drug Discovery Foundation stated that two multi-year treatment trials had found that epithalamin, from which epitalon is isolated, had imparted no severe adverse events in older adults, and that preclinical trials supported a favorable safety profile.35 Ten years later, a systematic review published in 2025 stated that information regarding critical issues about this peptides safety is missing.1 In terms of human trials, the best case we have in support of epitalons safety is a 2002 trial involving 162 patients in which no one in the epitalon group reported serious side effects.36 At the same time, the U.S

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Use typically relates to experimental or off-label contexts rather than approved medical treatment

Phenolic content and antioxidant activity of olive extracts Food Chem