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Activated Caspase 9 can further activate Caspase 3, a critical effector enzyme in apoptosis

There exist some studies on Nrf2, a key factor of oxidative stress, but on the one hand, Nrf2 has preventive oxidative and anti-inflammatory effects on normal cells, on the other hand, it can promote tumor metastasis and induce drug resistance [250, 251]

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

All raw data, including search engine output have been deposited to PRIDE 78 with the following identification: PXD052340

Either way you slice it, one needs the other to function properly and reduce oxidative stress