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It is recommended that warfarin sodium tablets, USP therapy be initiated with a dose of 2 to 5 mg per day with dosage adjustments based on the results of PT/INR determinations.17,18The lower initiation doses should be considered for patients with certain genetic variations in CYP2C9 and VKORC1 enzymes as well as for elderly and/or debilitated patients and patients with potential to exhibit greater than expected PT/INR responses to warfarin sodium (see CLINICAL PHARMACOLOGY and PRECAUTIONS)

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It can also lead to neurological problems if left untreated

Contraindications include pregnancy or breastfeeding, active or suspected cancer, and severe liver or kidney disease

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