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PMID: 39747971 Brain Res Bull Nerol ameliorates cognitive dysfunction in vascular dementia rats by inhibiting mitochondrial oxidative stress and reducing hippocampal senescence

They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]

Activation of the Wnt/-catenin pathway can be used as a predictor of primary AA/P resistance in metastatic castration-resistant prostate cancer (mCRPC), 314 and CRC is the main research object of Wnt inhibitors in clinical trials

Once reconstituted, tirzepatide should generally be used within 28 days, provided it is kept refrigerated