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By reducing the inflammatory load of adipose tissue, weight loss and adipokine normalization may therefore represent an indirect but clinically meaningful mechanism by which GLP-1RAs influence thyroid autoimmunity

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In a long-term study (10 years follow-up), including 86 patients with adult-onset pituitary disease who received HGH replacement therapy, four patients died, one from renal carcinoma, one from omental cancer, one from pulmonary edema (probably secondary to an acute myocardial infarction), and a fourth from cerebral infarction

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However, no peptide has been proven to prevent autoimmune disease in humans, and genetic susceptibility involves multiple factors beyond what any single intervention can address