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doi: 10.3390/ijms21228499 193 BromfieldJJ

The reversible addition of -CH 3 groups is catalyzed by two enzymatic families, referred to as writers and erasers. Notably, DNA methyltransferases (DNMTs) are a large group of writer enzymes involved in de novo methylation and its maintenance, whereas Ten-eleven translocation (TET) dioxygenases primarily act as erasers catalyzing DNA demethylation (Fig