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Conflict of interest The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Changes in BBB integrity, endothelial receptor and transporter function, vascular dysfunction, amyloid burden, and neuroinflammatory status can influence nanoparticle penetration, biodistribution, cellular uptake, and target engagement (Haqqani et al., 2024)

Fadilah NIM, Ahmad H, Abdul Rahman MB, et al

If you plan to use the same vial through a dose escalation to 4mg, the 2mL reconstitution becomes impractical

Drink clear or ice-cold drinks (like water or unsweetened tea) & limit alcohol intake