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LMK235 also significantly promoted the release of MDA and Fe 2+ (Figures 4 B, C), whereas it decreased GSH (Figure 4 D)

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It would be beneficial if compound 102 can inhibit Hv1 at the same time while activating GPX4, as both lead to the reduction of ROS and neuroprotective function

Conversely, the interaction between ROS and the NF-B pathway also involves the activation of antioxidant gene expression, which helps protect against ROS damage [223]