glutathione with electrophile Electrophiles modulate reductase activity via alkylation and upregulation of glutathione biosynthesis is made oxidative stress analysis Selective covalent targeting of GPX4
Selective covalent targeting of GPX4 using masked nitrile oxide electrophiles Nature Chemical Biology Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes What is Glutathione Glutathione Reporter Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Beyond detoxification: Pleiotropic functions of multiple glutathione S transferase isoforms protect mice against a toxic electrophile PLOS One
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