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This study found, that in the sperm cells of the male mouse model lacking Fis1 , mitophagy defects, abnormal mitochondrial accumulation, and severe morphological abnormalities led to physiological defects in sperm cells

Hepatic hemodynamic, non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

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This phenotype was manifested in the accumulation of lactic acid, pyruvate, and carnitine, increased alanine aminotransferase and aspartate aminotransferase levels in plasma [72], suppressed ETC activity, and reduced mitochondrial membrane potential ( m ) [79]