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The significant depletion of PON1 starting from Stage II indicates that oxidative stress becomes a dominant feature with the onset of parenchymal infiltration and granulomatous burden

Oxysterols and cell differentiation: Oxysterols can influence the differentiation of many cell types, and this was first studied in skin, where 22 R - and 25 R hydroxycholesterol were shown to induce human keratinocyte differentiation