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Absence of Common Growth Hormone Side Effects: Because AOD-9604 does not bind to growth hormone receptors or elevate IGF-1, it avoids edema and fluid retention, joint pain and stiffness, carpal tunnel syndrome, glucose elevation and insulin resistance, increased cancer risk concerns from IGF-1 elevation, organ growth or acromegaly features with long-term use, and thyroid function suppression

doi: 10.1007/S11694-024-03049-W 43

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells