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Description

J.HargreavesR

Note: There is evidence that constituitively expressed COX-1 plays a role in mediating the acute onset of inflammatory responses, while inducible COX-2 plays a more major role in the chronic maintenance of inflammatory responses (Perrone et al, 2010)

10.1056/NEJMoa1105185 161 RanF

A: The injection should not be used in individuals with hypersensitivity to diclofenac or other NSAIDs, as well as patients currently experiencing active peptic ulcers