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thus, cells depleted of GSH may be unable to activate caspase-mediated apoptosis

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Glutathione functions extensively in tissues and organs throughout the body

Funding This research was funded in part by the National Health & Medical Research Council of Australia (Grant No

In various embodiments, the peptide comprises, consists essentially of, or consists of: (a) 8 or more contiguous amino acid residues from the sequence Xaa 1 Xaa 2 Xaa 3 Xaa 4 KISQAVHAAHAEINEAGRESIINFEKLTEWT [SEQ ID NO:124], wherein Xaa 1 is absent or is S, Xaa 2 is absent or is a hydrophilic amino acid, Xaa 3 is absent or is a hydrophilic amino acid, and Xaa 4 is absent or is one or more hydrophilic amino acids (b) 8 or more contiguous amino acid residues from the sequence Xaa 1 Xaa 2 Xaa 3 KISQAVHAAHAEINEAGRESIINFEKLTEWT [SEQ ID NO:125], wherein Xaa 1 is absent or is S, Xaa 2 is absent or is a hydrophilic amino acid, and Xaa 3 is absent or is from one to ten hydrophilic amino acids, (c) 8 or more contiguous amino acid residues from the sequence Xaa 1 Xaa 2 KISQAVHAAHAEINEAGRESIINFEKLTEWT [SEQ ID NO:126], wherein Xaa 1 is absent or is S, and Xaa 2 is absent or is from one to four hydrophilic amino acids, (d) 8 or more contiguous amino acid residues from the sequence SKKKKKISQAVHAAHAEINEAGRESIINFEKLTEWT [SEQ ID NO: 127], (e) the sequence of any one of SEQ ID NOs: 124 to 127, (f) 8 or more contiguous amino acid residues from the sequence KISQAVHAAHAEINEAGRESIINFEKLTEWT [SEQ ID NO:128], (g) the sequence of SEQ ID NO: 128, (h) 8 or more contiguous amino acid residues from the sequence SIINFEKL [SEQ ID NO: 129], (i) the sequence of SEQ ID NO: 129, (j) 8 or more contiguous amino acid residues from the sequence ISQAVHAAHAEINEAGR [SEQ ID NO: 130], (k) the sequence of SEQ ID NO: 130, (l) or any combination of any two or more of (a) to (k) above