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CNGCs genes, encoding plasma membrane Ca+-permeable channels, showed sustained upregulation, suggesting a key role in mediating Ca + influx and initiating intracellular signaling during salt stress

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It is possible that these variants have impaired folding and localisation, although R169W has previously been shown to localise normally to the membrane 53

Though for decades ACs were thought to be only a transport form of acyl-moieties into mitochondria, recent studies have elucidated the active role of ACs in the regulation of energy metabolism and proposed AC accumulation as a link to insulin resistance 15,26,30,31

GSH-independent enzymes such as peroxiredoxins play important roles in redox homeostasis in the endoplasmic reticulum of tumor cells