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While this review concentrates on PD it is worth noting that oligodendrocytes, which are heavily loaded with pathological glial cytoplasmic inclusions in multiple system atrophy (MSA) patients, are also cells with high endogenous -syn and a high metabolic profile

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Evidence from several animal studies demonstrates the safe and effective use of antioxidants such as N-acetylcysteine (NAC), a thiol compound and precursor of glutathione (GSH), to overcome CWA-induced oxidative stress and associated acute lung injuries

In urethane-anesthetized female Wistar rats, L-theanine could reduce substance P-induced bladder hyperfunction through inhibiting pro-inflammatory protein kinase C (PKC)/ERK/NF-B/intercellular adhesion molecule 1 (ICAM-1)/IL-33 signaling, oxidative stress, apoptosis, autophagy (99)

Anderson AC, Yanai I, Yates LR, Wang L , Swarbrick A, Sorger P, Santagata S, Fridman WH, Gao Q, Jerby L, Izar B, Shang L, Zhou X