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Many different kinds of drugs have been utilized in experiments by blocking the Ca 2+ influx, mROS, and apoptosis in rodent crush injury models, such as voltage-gated calcium channel blockers, antioxidant plants, and trace elements [4, 7, 11,12,13]

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Via AMPK and SIRT1 signaling, melatonin enhances adiponectin and restrains leptin hypersecretion, improving metabolic flexibility (239)

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