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To establish a DTXresistant subline, a multiphase stepwise selection protocol was applied over an 8week period

In the Phase 3 GAIA (CLL13) clinical trial,58 patients with CLL who were fit and had no TP53 gene abnormalities were randomized in a 1:1:1 ratio to receive six cycles of chemotherapy: one to six cycles of chemoimmunotherapy (fludarabine-cyclophosphamide-rituximab or bendamustine-rituximab) or 12 cycles of venetoclax-rituximab, venetoclax-obinutuzumab or venetoclax-obinutuzumab-ibrutinib

[0529] In certain embodiment, the transmembrane domain of the CAR comprises a CD8 transmembrane domain

The interplay between -synuclein and microglia in -synucleinopathies

Jeong, W., Yoon, H