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Medical Consensus: High Serum B12 in Supplementers is Safe The medical community broadly agrees that high serum B12 levels resulting from supplementation are safe for individuals with no underlying health issues

Larraufie P, Roberts GP, McGavigan AK, et al

If you havent been taking vitamin B12 supplements for anything longer than a few months, you may want to start by taking 2,000 micrograms (mcg) of vitamin B12 once a day for two weeks to replenish your stores