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By activating the AhR signaling pathway, it inhibits airway inflammation, achieving immune regulation of the gut-lung axis (145)

Detailed study of cellular and molecular mechanisms of bilirubin production, circulation, and metabolism provides new drug targets, especially for damage caused by bilirubin on brain cells, ear damage, etc

The recent evidence shows that the dUTPase protein encoded by EBV and HSV-1 can be transported to the brain via exosomes, where it induces pro-inflammatory cytokine release (e.g., IL-1, IL-6, TNF-) from endothelial cells, astrocytes, and pericytes, thereby degrading tight junction proteins, disrupting BBB integrity and inducing neuroinflammation [80]

On the basis of these findings, we developed potential therapeutics for endometriosis-targeting disease lesions at peritoneal surfaces and tested their activity in baboon endometriosis models