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The mitochondrial DNA encodes for all the RNA involved in protein synthesis in the matrix but also for 13 proteins that are subunits of the ETC complexes: seven subunits in Complex I, one in Complex III, three in Complex IV, and one in the ATP synthase (sometimes called complex V)

Macrocyclic lactone Rapamycin, a macrocyclic lactone isolated from Streptomyces hygroscopicus , is known for its immunosuppressive and antimicrobial properties due to its ability to inhibit the mTOR pathway, thereby promoting autophagy [63]

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