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The efflux of soluble amyloid fibrils in the brain is facilitated by various clearance mechanisms including the blood brain barrier, blood-CSF barrier, the glymphatic drainage system, and intramural periarterial drainage [189]

[1] A review of literature shows that the prevalence of PA is higher in Northern Europe, especially in Scandinavian countries, and among people of African descent, and that increased awareness of the disease and better diagnostic tools might play a role in apparently higher rates of incidence

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