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This results in excessive formation of the dipeptide -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline

doi: 10.3389/fendo.2023.1122709 215 GrenhamSClarkeGCryanJFDinanTG

Moreira-Pinto B, Costa L, Felgueira E, Fonseca BM, Rebelo I

Dans ltude Lee & Padgett (2021), 14 des 16 patients (87.5%) ont rapport un soulagement significatif

Notably, while total FOXO4 protein levels remained consistent between young and elderly men, a striking age-dependent shift in its subcellular localization was observed: FOXO4 predominantly resided in the cytoplasm in young Leydig cells but translocated to the nucleus in aged cells