lipid hydroperoxides glutathione (GSH) redox cycle in hydroperoxide metabolism. GSSG, The glutathione peroxidase (GPX) system

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Structural analysis showed that when human DNMT1 was not bound to DNA, the RFTS domain could bind to the MTase domain directly through a hydrogen bond and bind indirectly through a CXXCBAH1 linker, thus forming an auto-inhibitory conformation

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Dysregulation of this equilibrium drives cardiac and vascular pathology through mechanisms such as mitochondrial dysfunction, altered substrate preference, and metabolic pathway reprogramming

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