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A study published in the Proceedings of the National Academy of Sciences found that aging is associated with a 47% decrease in the catalytic subunit (GCLC) and a 52% decrease in the modulatory subunit (GCLM) of glutamate-cysteine ligase, the rate-limiting enzyme for glutathione production

Zhongguo Dang Dai Er Ke Za Zhi 9, 548

However, LAB and more specifically certain Lactobacilli strains are the most important GABA producers in the gut [175]

JAMA 326 , 926 (2021)