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Sampson UK, Fazio S, Linton MF

SEMA3A is a member of the semaphorin family with an Ig-like C2-type domain and is involved in axon guidance and neuronal connectivity

However, randomized trials on its potential use for cancer prevention have mostly yielded negative results (117, 123)

Medicine (Baltimore) 53:307323 Reddy S, Smith DB, Rich MM, Leferovich JM, Reilly P, Davis BM, Tran K, Rayburn H, Bronson R, Cros D, et al (1996) Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy