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Anastasiou D, Poulogiannis G, Asara JM, Boxer MB et al (2011) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

Both NAD and B12 injections are administered as shots, so there may be a mild level of discomfort

Epilepsy Based on a placebo-controlled trial of adjunctive therapy for treatment of complex partial seizures, Depakote was generally well tolerated with most adverse reactions rated as mild to moderate in severity

This concern is particularly relevant for hormone-sensitive tissues like breast, prostate, and colon